Experimental Study On Pharmaceutics And Pharmacodynamics Of Jizhi Dropill

Jizhi dropill bring along jizhi syrup.Jizhi syrup is a complex prescription pharmaceutics of Chinese drug which is recorded in pharmacopeia .Come in to mark for many years. Clinical efficacy definite.Its composition are Jinqiaomai , Sijiqing , Yuxingcao , Ziyuan, Qianhu, Zhiqiao, Mahuang and Gancao.To cure acute bronchitis, cough etc.But because jizhi syrup carry defecosaturation, diaabetes people cannt take it.What's more,it has only a formulation,confine it's application.So, this thesis chenge the syrup into the dropill guideing in the market and patient-oriented concept.This formulation have so many excellence,for example:highly bioavailability,quik action and convenient take.It fit to all the people cluding diaabetes people. Fabric accommodation simple,cifp low etc.Abstracted art of medicinal material is coincide with syrup,and essential oil is inclused with β-cyclodextrin into inclusion compound so that the bend loss of qualtity of essential oil bring low.With acquisition ratio of inclusion compound and essential oil entrapment efficiency appearing as appraisal index inspect tumperiture , tine and proportion btween between β-cyclodextrin and essential oil there factors.According to orthogonal test optimize the inclused condition.The condition :temperiture is 50℃,time is 2 hour and proportion between P-cyclodextrin and essential oil is 8:1.With the granule roundness and solution time of the pills, appearing as appraisal index select The ground plasm and the condensing agent. The results are that PEG4000 appear as ground plasm, simethicone appear as condensing agent ,the proportion between powder of drug and ground plasm is 1:1.5. With time and weight variation ofthe pills appearing as appraisal index,select dropill condition by orthogonal test.The conditions: dropill temperiture is 80"C,dropill distance is 2cm, dropill velocity is 20 drop/min.We identify Sijiqing> Yuxingcao> Mahuang and Zhiqiao with thin layer chromatographic method. Their repeatability is good, and specificity high.With Naringin appearing as object and index, deter-minate content by HPLC.The result of deter-mination is that the jizhi dropill comprise Zhiqiao no lesst han 0.2mg/pill by accounting with Naringin. Pharm-acodynamics test certificate: drug effect is coincide between the dropill and the syrup.They all relieve cough in mice by ammon,loose bronchial plain muscle, prolong latency period of coughing in guinea pig,antagonize astriction of bronchial leading by histamine and phlegmonosis on auricula leading by xylene.Study in clinic certificate this formula had sure curative effects in healing acute bronchitis cough in cold. This test certificate jizhi dropill that its act is anchoring and quality holding. There are coincide in act and curative effects between formulation after reforming and old formulation.What's more this new formulation not only advance bioavailability, fasten avail, take easementlycarryeasy, fit to all the people eluding diabetic patient,but also fabricate easy, bring low cifp.