Study On The Effect Of Gynosaponins Compound On Mice's Learning And Memory

Gynostemma pentaphyllum(GP),a bitter cold innocuous Chinese tranditional medicine,is frequently researched in this twenty years over the world.In 1976,A Japanese man first found that GP contain Ginsenoside Rb1,and then many correlative industries began to study it in China and other countryies.GP can make nerve crntre calm, hypnosis,resist tensing up and tiredness ,bate cancer,prolong cellular natural life.Some studies had proved that GP can improve Mice's learning and memorial capabilities.This paper sticks to Chinese tranditional iatrology.The Gynosaponins Compound (GC) was maded up by some Chinese tranditional medcines.We discussed the GC how to effect Mice's learning and memorial capabilities.Polygala tenuifolia Willd, Poria cocos(Schw.)Wolf and Acorus tatarinowii Schott were distilled in water and then in ethanol. Excipients and GP saponins were filled in their disposal. Mixture Acorus tatarinowii Schott's volatile oil and the disposal.In this way,GC was made up.Acute intoxication test was made for observing GC's security.Because GC was made up with Chinese trandtional crude drugs, GC is likely innocuous.So we couldn't gain its half lethal dose (LD50).So we gained its maximal tolerable dose (MTD).There was no death of twenty rats,but some rats were poisoning:abnormal call, hyponoia, languishment,slow.The MTD of GC was above 21.5×103mg/kg...