Preparation Of Monoclonal And Polyclonal Antibody Against Human Immunoglobulin G(IgG) And Identification Of The Co-localization Of IgG And Heat Shock Peotein 70(HSP70) In Tumor Cells

Elevated level of serum Immunoglobulin was observed in patients with cancers of epithelial origin, including carcinomas of breast, colon, and liver and that was interpreted as humoral responses of host to cancer growth .Recently, Qiu et al. described in detail that human cancers of epithelial origin, including carcinomas of breast, colon, liver, lung, established epithelial cancer lines, produce IgG in their cytoplasm. Under normal conditions, heat shock proteins (HSPs) have multiple housekeeping functions, such as folding and translocating newly synthesized proteins, When the cell is injured or under stress, HSPs are responsible for the refolding and repairing of the damaged protein or facilitating the...