Preliminary Study On Biological Mechanisms Of Depression After Focal Cerebral Ischemia In Rats

Cerebral ischemic stroke has a high prevalence and survivors have more or less neurological function deficits, which have given rise to a large burden on society and patients' families. Neurological experts and researchers have been focusing on the question of how to improve the rehabilitation of patients with cerebral stroke and reduce disability. In recent years, mood disorders after cerebral stroke have been highlighted. In clinical practice, the incidence of post-stroke depression is high. It is reported that there are about 25%~75% surviors from stroke that result in depression eventually, which has a higher risk of incidence in the first 2 years. Post-stroke depression has a negative effect on recovery of neurological functions and aggravates cognitive impairment. The quality-of-life of patients with stroke is low and there is a high mortality rate. Although there have been a large number of studies involved in many aspects of ischemic brain injury, the biological mechanisms of post-stroke depression are still in the dark. Up to now, there have been two different main explanations for the biological mechanisms of post-stroke depression. Some researchers think that post-stroke depression is caused by the sociopsychological stresses while others consider it is the ischemic injury that influences the neurological circuit involved in regulating emotion. Some risk factors may give rise to post-stroke depression such as the history of family or individual mood disorder, living alone, history of stroke, a higher...