The Expression Of Livin In Non-small Cell Lung Cancer And Its Relationships With Caspase-3 And PTEN

[Background and Objective]Lung cancer is one of malignant tumors with the highest morbidity and mortality in the world. Although a variety of antitumoral measures including surgery, irradiation and chemotherapy are taken, the 5-year survival rate of lung cancer is still below 15%, mainly due to the carcinogenesis of lung cancer is a progression with many steps and phases and its mechanism is rather complex. Modern molecular biology studies have shown that the formation and development of malignant tumors are not only associated with abnormal proliferation and differentiation ,but also involved in inhibition of apoptosis. which was one of the important mechanisms in the forming of tumors. So, apoptosis and tumor became a new focus in molecular biological researches. Therefore, it is important to demonstrate the pathogenesis of tumor by studying the relations among apoptosis-related genes,tumor formation and progression,which will benefit to diagnosticate and develop novel therapies of induction of apoptosis in non-small cell lung cancer.Livin is a novel inhibitor of apoptosis protein with oncogene potentiality recently discovered. Livin gene is presented in several cancer cell lines,so it's close relation with the occurrence of tumors, Livin served as a new target for apoptosis-inducing...