The Relationship Of The Expression Of Connective Tissue Growth Factor And P27kip1 In Brain Glioma Tissues To The Tumour Grades

[Objective]: To investigate the relationship between the expression of CTGF mRNA﹑p27kip1 mRNA and the pathological grade in human gliomas.[Methods]: We used realtime polymerase chain reactions(RT-PCR) to detect the expression of p27kip1 mRNA and CTGF mRNA in 47 cases of human gliomas (23 cases of gradeⅠ～Ⅱand 24 cases of gradeⅢ～Ⅳ) and in 25 cases of normal brain tissues.[Results]: (1) The expression of CTGF mRNA in gliomas is higher than that in normal brain tissues(P<0.01), also the expression of CTGF mRNA in gliomas of gradeⅠ～Ⅱ(well-differentiated group) is much lower than that in gliomas of gradeⅢ～Ⅳ(poorly-differentiated group) (P<0.01).(2) The expression of p27kip1 mRNA in gliomas is significant lower compared to that of normal brain tissues(P<0.01), also The expression of p27kip1 mRNA in gliomas of gradeⅠ～Ⅱ(well-differentiated group) is much higher than that in gliomas of gradeⅢ～Ⅳ(poorly-differentiated group) (P<0.01).(3) The expression of CTGF mRNA is reversely correlated to the expression...