Investigation On The Relation Between Radon Exposure Inside An Emporium And Genetic Damage Of Peripheral Blood Lymphocyte

Objective: To estimete the effects of radon exposure on genetic damage of emporium workers by measurement of DNA length and micronucleus rate of peripheral blood lymphocytes.Methods: The indoor radon concentration was measured continuously 24 hours a day. The cytokinesis-block micronucleus and the single cell gel electrophoresis technique were applied to 40 objects to reflect the DNA damage by long term radon exposure.Results: The average radon concentration inside the emporium was 34.10+9.42 Bq/m~3 with the total effective dose per year of 1.0709 mSv. The average micronucleus rate was 1.475‰ and the kernel DNA length was 26.46 μ m. The correlation coefficients between accumulative dose with the age and the micronucleus rate were 0.378 (p=0.016) and 0.373 (p=0.018) , and those with the age and the DNA length were 0.172 (p=0.08) and 0.372(p=0.018 ) , respectively.Conclusions: The emporium indoor radon concentration was under the National and State standands. With the accumulative dose of radon exposure, the micronucleus rate of peripheral blood lymphocytes and the DNA length increased correlatively, indicating that long-term radon exposure could reduce...