The Brain-protective Effects Of Edaravone In Ischemia-reperfusion Gerbils

BACKGROUNDIschemia is a important cause of high mortality and high mutilation rate in elder . after blood flow decreased , cells dead rapidly in the core of the infarction area, and the surrounding zone ( penumbra ) , the decreasing of blood flow induced ischemic cascade , including iron cascade (necrosis) and protein cascade (apoptosis). which rapidly restore blood supply can save re-injury tissues. Paradoxically, restoration of blood flow to the ischemic tissues initiates a cascade of pathology that leads to additional cell or tissue injury, which is called ischemia-reperfusion (I-R) injury. So attacking of free radicals is one of the major injury mechanism with I/R. Recently, The key of ischemia stroke treatment are earlier thrombolytic therapy and brain protection. The thrombolytic therapy was limited by many conditions, such as time window , equipment et al, and the risk of brain hemorrhage, there are no more than 15% stroke patients accepting thrombolytic therapy per year in American. Thus edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186) ), a potent free radical scavenger, has been successfully applied in treatment of patients with acute cerebral ischemia. To our knowledge, To further investigate the brain-protective mechanism of Edaravone is important. To provide theoretical basis in clinical application of free radical scavenger early.OBJECTIVE...