The Study On Common Fragile Genes FHIT And WWOX In Epithelial Ovarian Carcinoma

Nowadays,malignant tumors are the most fearful diseases endangering the people,and also they mainly lead to death. Among all the gynecologic cancers, ovarian tumors represent the greatest clinical challenge.Since the early symptoms of ovarian cancers are obscure and secret, almost 2/3 of patients take on already advanced diseases, requiring major surgeries and intensive and often complex additional chemotherapy. Therefore, one of the aims in the cancer researches is to define the molecular mechanism leading to the initiation and progression of tumors.In 1996,Ohta et al. identified a candidate tumor suppressor gene FHIT at 3p14.2 by exon trapping experiment.FHIT is classified into the gene family HIT(histidine triad),and as the first common fragile gene to be found,it is easy to rupture. FHIT gene covers a genomic region greater than 1Mb ,and it is situated in the fragile site FRA3B.In 2000, Bednarek et al cloned the gene WWOX at 16q23.3-24.1 with the shotgun technique. WWOX spans a genomic region greater than 1 Mb in size and is the second most common chromosomal fragile site, connected with the fragile site FRA16D (16q23). FHIT and WWOX have been found allelic losses and abnormal transcription outcomes in many tumors.FHIT and WWOX, as the two earliest discovered fragile site genes,play a very important role in the gene family of suppressor genes,and they are closely connected with the initiation and progression of the tumors,also with the prognosis of patients. In...