| Objective: Significant low density lipoprotein (LDL) uptake by tumor cells led to the use of LDL as a discriminatory vehicle for the delivery of cytotoxic drugs. This study was to compare the cytotoxic effects of LDL-Aclacinomycin (ACM) complex and free ACM on human gastric carcinoma cell line SGC-7901 and human normal gastric fibroblasts (control cell). There was theoretical significance for drug targeting therapy on carcinoma cell.Methods: Human gastric carcinoma cell line SGC-7901 and human normal gastric fibroblasts were obtained by purchase and breeding, and made them for experimenting. LDL-ACM complex was obtained by incubating LDL with a large excess of ACM. The effects of LDL-ACM and free ACM on SGC-7901 cell the cytotoxic activity were investigated, the DNA synthesis inhibition and protein synthesis inhibition were also observed .The data was statistical analysed.Results: There was statistical significance between LDL-ACM and free ACM on SGC-7901 cell the cytotoxic activity(p<0.01) and the DNA synthesis inhibitory effect(p<0.002), and at some drug concentration (1.25～5.0 μ g/ml) there was obvious statistical significance(p<0.05). The comparison of LDL-ACM complex and...
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