The Effects Of Salvianolic Acid B-bererine Double Salt On Renal Lesions In Diabetic Rats

In recent years, the incidence of the diabetes mellitus (DM) rises gradually in the world, and much more efforts were paid to prevent diabetes as well as the resulted complications. Diabetic nephropathy (DN) is one of the most common microvascular complications of DM. Many patients with DM are predisposed to developing diabetic nephropathy and die from it. DN is now the single commonest cause of end-stage renal failure in industrialized country such as America, this trend also occurs in our country. Up to now, the pathophysiological mechanism responsible for DN has not been fully understood and DN hasn't been treated well yet. It seems to occur as a result of the interactions between metabolic and haemodynamic factors. Hyperglycemia and lipid abnormalities are the essential cause contributing to DN. Glucose -dependent pathway includes renal polyol formation, nonenzymatic reactions between the glucose and the free amino groups on proteins, lipids, and nucleic acids ,the formation of advanced glycation end products (AGEs), activation of protein kinase C, oxidative stress, and so on. Over expression of cytokine especially TGF-beta 1, abnormality of cell cycle and apoptosis also play important roles in the development of DN. So it is of great significance to study the mechanism of DN and find efective drugs for DN.The object is to investigate the effects of salvianolic acid B-bererine double salt (SBS) on renal lesions in diabetic rats. Salvianolic acid B (Sal B) is one of the water-soluble components from TCM-Salvia miltiorrhiza. Previous experiments have...