The Effect Of Resuscitation By Penile Intracorporeal Infusion In The Hemorrhagic Shock

Objective To investigate the feasibility, efficacy and safety of using the corpus cavernosum as a new emergency vascular access in dogs with severe hypovolemic shock.Methods 6 male dogs were divided into experimental group (group A) and control group (group B) at random, then they were anesthetized by intraperitoneal injection of 3% pentobarbital (concentration 3. Og/100 ml) at dosage of 30 mg/kg. Spontaneous respiration was maintained during the operation. After local skin sterilization, a femoral artery was punctured and a 16G catheter was inserted directly into the abdominal aorta for induction of rapid hemorrhage and MAP ( mean arterial pressure) monitored. The femoral vein was also incised and another catheter was inserted directly to the vena cava posterior for fluid infusion and CVP ( central venous pressure ) monitored. 1% heparin was performed to keep catheters patent. Left forefinger and thumb fixed the sponge body behind of penis bone after the local skin of penis w.as sterilized, and chosen any one side of the corpora cavernosum without vein area to puncture. After these were prepared, all animals were kept stable for 30 minutes. Basal MAP, CVP, HR (heart rate), and R (respiration) were measured continuously. Blood was then withdrawn through arterial catheters and collected in CPDA containing bags to reduce MAP to 40- 60mmHg according to the weight 80 ml/kg x 40% in 30 minutes, and MAP was maintained at the level for 60 minutes. All above indexes were measured again during this shock period. Experimental group dogs were actively resuscitated via intracavernous route using sodium lactate ringer's injection and whole blood. The control group dogs were resuscitated by femoral vein. The indexes were again measured 15,30,60, 90 and 120 minutes after infusion to observe the effect of resuscitation.