Objective to get a better therapeutic effect by treating the patients of trauma, severe sepsis or MODS with anti-inflammatory and immunostimulation together, explain the feasibility of immunoregulation and explore more suitable therapeutic way for these kinds of diseases.Methods 24 patients (17males, 7females, average age: 51.3, from 19 to 73) in ICU who were treated classically for severe trauma or severe sepsis with Marshall Score from 5 to 20 were divided into experimental group A and control group B randomly. The group A was treated with anti-inflammatory drug(Ulinastatin) and immunoregulation drug(TP-5) additionally, while the group B had no additional anti-inflammatory and immunoregulation therapy as a control. The blood specimens were collected before any treatment, 3 days and 8 days after treatment or before death. The level of HLA-DR expression on the CD14+ cells, TNF-α, IL-6, IL-10 were analyzed by FCM and ELISA, and they were evaluated by APACHEⅡ. The data (x±s) was assessed by the Student's t test using the statistic software SPSS 10.0.Results1. there were insignificant difference of HLA-DR expression on the CD14+ cells, TNF-α, IL-6, IL-10 between group A and B before any...
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