Expression And Significance Of E2F3,pRb And MCM2 In Prostate Cancer

Objective: To investigate the expression and significance of E2F3, in prostate cancer, and its relationship with the expression of pRb,MCM2. The expression of MCM2 was also compared with Ki67.Methods: The expression of E2F3,pRb,MCM2 and Ki67 in sample of 10 normal prostate tissues (NP),20 benign prostatic hyperplasia (BPH) and 49 prostate cancer (PCa) were examined by EliVisionTM plus immunohistochemical stain.Results: The rate of positive for normal prostate,BPH and prostate cancer was 10%(1/10),20%(4/20) and 63.27%(31/49) respectively. The expression level of E2F3 in prostate cancer was much higher than in normal prostate (P<0.01),BPH (P<0.01),and it was related positively with clinical stage (P<0.01) and pathological grade (P<0.01) of prostate cancer. The expression level of E2F3 in PCa was negatively correlated with pRb expression (P<0.01) and positively correlated with MCM2 expression (P<0.01). The expression level of pRb in PCa was negatively correlated with MCM2 expression (P<0.01). The expression level of E2F3 in prostate cancer was related positively with PSA (P<0.05). However, the expression...