The Research Of The Apoptosis And The Change Of Proliferating Ability Induced By ECSP In Malignant Tumor

Steep pulsed electric fields can cause irreversible electrical breakdown on the tumor cell membrane and results in tumor cells death, it would become a new non-invasive or mini-invasive physical approach in the treatment of neoplasm. The proliferating ability of tumor cells in the edge of the center (the area around the center of treatment zone ) after treatment is an important factor that influences the effect of energy controllable steep pulse (ECSP) therapy. In this study, the tumor models in vivo and in vitro were treated by energy controllable steep pulse, to discuss the change of the proliferating ability and apoptosis induced by ECSP in the the area around the center of treatment zone and its possible mechanism and provide theories for the clinical experiment in the future.