The Relationship Between TIMP-1 And LSTR1's Tumor Correlated Biological Behaviour

Colon cancer is one of the most frequent malignant cancers in our country, the morbility rate of which increases year by year. Although the colon cancer patients could be partly cured by operation, chemotherapy, radiotherapy and other combined therapies, it is indicated that about 30% of the total patients died of recurrence and metastasis in 5 years. So the studies and investigations on the mechanism of invasion and metastasis are the hotspots in nowadays study. Current researches indicate that the invasion and metastasis of cancer is a complicated process with several steps, of which the degradation of the basement membrane around the cancer is most important in invading the adjacent connective tissues and then spread to other part of the body. The loss of basement membrane integrity is closely related to local diffusion, faraway metastasis, and bad prognosis. The matrix metalloproteinases secreted by the cancer tissues could induce the degradation of the extracellular matrix and basement membrane, thus promote the invasion and metastasis of cancer. Meanwhile, inhibitors, which could inhibit the activities of the matrix metalloproteinases, could maintain the integrity of the basement membrane and prevent the invasion and metastasis. At present, there are few studies on the role of matrix metalloproteinase and its inhibitor in colon cancer in our country. The first stage of our studies indicated that the expressions of TIMP-1 are different in the three types of colon cancer cell strains with different metastasis potentialities. The expression of TIMP-1 in LSTR1 cell strain with low metastasis potentiality significantly increased. To further identify the effect of TIMP-1 on LSTR1 metastasis...