The Role For Phospholipase C-γ1 In Tumor Necrosis Factor-α-Induced Apoptosis In Human Glioma Cell Line SWO

Gliomas are the most common form of primary brain tumors, with high-grade gliomas constituting the most serious as well as the most common group. The prognosis for malignant gliomas remains poor due to their critical locations, infiltrative growth and relative resistance to radiation and chemotherapy. The median survival time of the patients with this disorder has been estimated as =2 years, even when various therapies are combined. A variety of new approaches to overcome this resistance have been tried, but the results still remain unsatisfactory.Tumor necrosis factor-alpha (TNF-a) has been considered to be a potent anti-cancer agent that can effectively kill tumor cells. It has a wide range of biological activities, including cytotoxic and cytostatic...