NOD2/CARD15 Gene Mutation And Crohn's Disease In The Chinese Population

Background and Objictive:Crohn's disease(CD) is a main type of inflammatory bowel disease(IBD),and is a segmental transmural inflammatory disease of gastrointestinal tract. The mobidity of CD is about 1.5-2 in European and American.CD is seldom reported in the past,but in these years, the incidence increased continuosly.So far the cause and the pathogenesis remains unclear, the clinical manifestations are diverse, which is difficult to diagnosis in early stage and easily misdiagnosed.It cann't cure and easily to relapse,which damaged people's health deeply.Recent studies have revealed coding region polymorphisms in NOD2/CARD15 which are significantly associated with susceptibility to CD.They verified the three major polymorphisms in NOD2/CARD15 -R702W,G908R and 3020inC which is genetically associated with CD in European and American population.They also testify it is associated with the clinical features and the position of illness.The outcome was testified in German,Australian,and England population,and so on,but not in Japanese,Korea, Hongkong and Chinese Zhejiang population.The main function of NOD2/CARD15 is as a submit signal of Nuclear transcriptional factor k B (NF-κB ) . The NOD2/CARD15 product is a protein composed of two NH2 terminal caspase recruitment domains,a centrally located mucleotide binding domain,and multiple COOH terminal leucine rich repeats which acts as a receptor of bacterial (LPS) and muramyl dipeptide (MDP). NOD2/CARD15...