Association Between HLA-DQA1 Alleles And H Pylori Infection In Bai-ethnic Children From Kunming

AIM: To find the susceptible or resistant genes of H pylori infectionin Bai-ethnic children of Kunming,and to explore the immunogenetic mechanism of H pylori infection.METHODS: Polymerase chain reaction-sequence specific primers(PCR-SSP)technique was used to detect the allelic distribution of HLA-DQA1 in Bai-ethnic children with or without H pylori infection(n=32,34 respectively) from Kunming.H pylori infection was identified by combination of dot-immunogold filtration assay and immunogold technique, allelic frequencies of HLA-DQA1 in two groups were calculated,and comparison of allelic frequencies were made by the Chi-square or Fisher's exact test.RESULTS: The allelic frequency of HLA- DQAl*01040l or *0402 wassignificantly lower in children with H pylori infection than in children without H pylori infection (0 vs 15%, X~2= 0. P = 0.001, P_c=0.014 , OR=1.172 , 95%CI = 1.062-1.294). CONCLUSION: HLA-DQA1*010401 or *0402 may resistance gene of Hpylori infection in Bai-ethnic children from Kunming.