Long-term Effects After Sirolimus-eluting Stents Implantation For The Treatment Of Coronary Artery Disease: An Intravenous Ultrasound Study

Objective The relationship between the in-stent restenosis (ISR) after sirolimus-eluting stent (SES) placement and vascular neointimal hyperplasia was assessed by intravenous ultrasound; The long-term clinical outcomes then were evaluated. Methods 29 patients with coronary artery disease underwent sirolimus-eluting Bx-Velocity stents placement(SES group: 21 patients) or bare metal stents placement(BMS group:8 patients).The target vessel was:LAD: 21;D₁: 1;LCX:6;RCA: 5. After stent placement, aspirin and clopidogrel were administrated (administration lasting time :SES group ≥ 9 months;BMS group ≥ 3 months). Intravascular ultrasound checks(IVUS) were performed after placing stents 11.5±6.3 (4～23) months. All indices concluding In-stent Area, Minimal Lumen Diameter, Neointimal Hyperplasia Area,External Elastic Membrane Area were measured by intravenous ultrasound. Pattern of in-stent restenosis were then identified.At the same time,the improvement of cardiac function was evaluated by echocardiography check-up.Results 33 stents were implanted successfully (SES:n=25;BMS:n=8).The sizes of the stents implanted were: 2.8±0.4)× (22.6 ±6.4) mm, (2.9±0.6) × (23.5 ±3.8) mm.Among the vessels of SES group at the follow-up,no in-lesion restenosis occurred.But at the segment distal to the stent,two restenosis(edge effect) happened. IVUS results: SES group vs BMS group : In-stent Area: 6.5±2. 1mm² vs 6.3± 1.9...