Research On Biodegradation Performance Of Degradable Bone Repair Materials Of Poly L-Lactide/β-Tricalcuim Phosphate System

The bone default is mainly induced by the wound, the infection, the tumors, and congenital diseases. The feasible cure for these diseases is to repair bone defaults to recover the function by using bone repair materials (BRMs) in clinical use. Although poly L-lactide (PLLA) authorized by FDA shows some good bone repair performances among various BRMs, but it still reveals some shortages, for example, the low mechanical strength would lead the implant destroyed, and the acidic degradation productswould cause the local inflammation. Moreover,β-tricalcium phosphate (β-TCP) ceramic is biocompatible and similar in composition with natural bone, it meansβ-tricalcium to be a usable bone repair material. But the match ofβ-TCP with the natural bone is not very well in biomechanical property, the application in clinic of the material has been limited. Therefore, a new kind of bone tissue engineering material has been paid much attention to, which is constructed by the combination of bioactive factors with biodegradable scaffolds made of PLLA andβ-TCP.In bone tissue engineering, biodegradable performance of the scaffolds is the key factor in application. Due to its conveniency and similarity, the in vitro experiments were often made to investigate the structure, the mechanical, and the...