| Obesity have become major public health concerns recently, not only because of their increasing prevalence in epidemic proportions but also because of their frequent association with diabetes mellitus and major cardiovascular risk factors, which are responsible for excess morbidity and mortality. Obesity is a disorder of energy balance and is associated with hyperinsulinemia, insulin resistance and abnormalities in lipid metabolism. Evidence is emerging that consumption or supplementation of foods rich in soy isoflavones may have a beneficial effect on obesity in animals and humans. In this paper, we studied the effects of SIF on male SD obese rats, which induce by high fat, and its mechanism.In experiment of rats made obese by high-fat diets, rats were divided 2 groups. Rats in base group were feed base diets, another group was feed high-fat diets, which is consist of 35 percent fat in total energy. The average body weights of rats in high-fat group is higher than that in the base group plus 1.4 times of standard deviation is criterion. In the end of experiment, the above results indicated that we successfully made the rat obese model.The selected obese rats were randomly divided into four groups. All rats were given high-fat diet. One control group and three SIF groups that were gavaged with water solutions with SIF at doses of 0 mg/kg.BW, 50 mg/kg.BW, 150 mg/kg.BW, and 450 mg/kg.BW, respectively. In the...
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