Protective Effects Of Glutamine On The Intestinal Mucosal Injury In Patients Undergoing CPB

Objective To observe the changes of plasmic level of Diamine Oxidase(DAO) and Tumor Necrotic Factor (TNF- a) happened after L-Glutamine(GLN) used orally in the patients undergoing CPB and discuss the mechanism of protective effects of L-Glutamine (GLN) on intestinal mucosal injury caused by CPB.Method 24 patients undergoing CPB were divided randomly into two groups: L-Glutamine(Gln) group(n=12) and control group (n=12).In Gln group , marzutene-s granules (L-Glutamine)( 0.50g. Kg^-1, day^-1 )was given for seven days before CPB. While the control group received placebo. Plasmic levels of DAO and TNF- a were measured at baseline (seven days preoperatively) and 2h , 24h, 72h after CPB .The plasma concentrations of DAO were detected by biochemical means, Of TNF- a by Enzyme Linked Immunosorbent Assay (ELISA) technique.Result Levels of DAO and TNF- a were no significant difference in both group before CPB(p>0.05) and increased significantly at 2h ,24h after CPB(p < 0.05) respectively, then decreased .Levels of DAO were higher at 72h after CPB than before CPB, while TNF- a returned to normal at 72h after CPB. In Gln...