Effect Of Early Short-term High-volume Hemofiltration On Severe Acute Pancreatitis Dogs With Myocardial Injury

Objective: Severe acute pancreatitis is a acute abdomen with many complications and high mortality.The incidence of SAP is rising in recent years.The main cause of death in SAP is multiple organ dysfunction syndromes(MODS).Now, "overwhelming inflammation" is considered to be the critical mechanisms of MODS.That continuous renal replacement treatment could remove a lot of inflammatory mediators recently has been found.Among them, high volume hemofiltration (HVHF)is more valid in renal replacement and inflammatory mediators removement.In addition,in ex-pancreatic organ injury,many studies focus on hepatic injury, pulmonary injury,renal injury, and so on, yet there were few studies about myocardial injury.However, cardiovascular decompensation is the complication with the highest mortality in acute pancreatitis,though the interest on it is inadequate in clinical practice.The aim of this study was to investigate the relationship between inflammatory mediators and myocardial injury induced by SAP and evaluate the feasibility of early short-term high-volume hemofiltration on treatment of the myocardial injury induced by SAP.Methods: Severe acute pancreatitis(SAP) was induced by the retrograde injection of 1ml/kg of 5% sodium taurocholate (STC) in the pancreatic duct. Sixteen healthy hybrid dogs were randomly allocated into A and B group (n=8). The animals in group A were received the treatment of HVHF, while Group B was just a control group.Dogs were killed after six hours of treatment.vital sign were mere measured at before model establishment and 0h,2h,4h,6h after hemofiltration. Serum myocardial enzymogram,The level of TNF-α,IL-6 in plasm were measured at before model establishment and 0h,2h,4h,6h after hemofiltration.Specimens of myocard were collected for histopathologic analysis and wet myocardial...