Study On The Expression Of P53 And P63 Protein In Pterygium

Purpose To study the clinical significance of the expression of P53 and P63 gene in pterygium and normal conjunctivae. To investigate the correlation between P53 P63 and pterygium.Methods 30 cases of pterygium tissures operated in our hospital and 5 cases of normal body conjunctivae were alternatively stained by histochemical P53 and P63.The P53 and P63 expression were compared between two groups.Results Hematoxylin and eosin stain showed pterygium was a disease mainly with proliferation. The P53 and P63 protein was expression in pterygium tissures. The expression of P53 and P63 was significantly higher in pterygium than in normal conjunctiva epithelium The positive rate of the P53 protein in pterygium was significantly higher than normal conjunctivae (U=2.500, W=17.500, Z=-4.467, P<0. 05) . The positive rate of the P63 protein in pterygium was significantly higher than normal conjunctivae (U=2.500, W=17.500, Z=-3.967, P<0. 05) .Conclusion Proliferation were seen in pterygium. The P53 and P63 gene is correlation in pterygium. The results indicated pterygium may coursed by the imbalance between apoptosis and proliferation.