| Background and Objective Gastroesophageal reflux disease (GERD) is one of the most common diseases of the gastrointestinal system. GERD has many symptoms, including typical symptoms like heartburn, regurgitation and dysphagia, atypical presentations such as odynophagia, nausea, as well as extra-esophageal manifestations like chest pain, chronic cough, asthma and laryngitis. These symptoms of GERD may have a huge impact on the patients' mental health and social function, and reduce their quality of life. Nowadays, due to the unhealthy life style and the changes in people's dietetic custom and social age structure, the global prevalence of GERD is getting higher. However, so far the effective examination means has not been established, which limits the diagnosis of GERD. On the basisof the dynamic monitoring esophageal pH in 104 cases with GERD, this text compares the clinical characteristics of esophageal acid exposure and Helicobacter pylori infection in RE and NERD, and then proceeds to the examination of gastroscopy and the analysis of the correlation between the 24H pH and GERD. In a word, this paper aims to explore the pathogenesis of reflux esophagitis (RE) and non-erosive reflux disease (NERD), and further more provide scientific basis for the clinic diagnosis and treatment of RE and NERD.Materials and Methods: CTD-synectics dynamic pH instrument and computer procedure software were used to monitor and analyze 24h pH esophagus value of the 104 cases. Johson and DeMeester's 6 parameters were adopted to evaluate the patients' reflux degree and calculate the accurate time of esophageal attaching stomach acid. And the examination of gastroscopy and the detection of Helicobacter pylori infection were conducted in all patients.Results: The parameters were respectively (1.25±1.05; 1.52±1.35; 0.98±1.58; 27.0±12.0; 0.5±0.18; 5.4±5.96) of the controlled, and (6.25±8.27; 9.35±11.01; 3.05±6.93; 140.91±230.90; 3.33±4.93; 19.16±36.28) of the tested (P<0.01). In the 104 GERD patients, 35 cases were diagnosed as RE, 67 cases as NERD and 2 as Barrett's esophagus by gastroscopy. The parameters were respectively (8.48±7.75; 11.39±11.04; 4.24±6.03; 137.54±115.94; 4.46±5.00; 21.94±24.22) of Reflux Esophagitis, and (6.05±8.51; 8.56±11.00; 2.52±7.41; 146.87±275.04; 2.84±4.88; 18.28±41.67) of Non-Erosive Reflux Disease (P>0.05). The positive rates of Helicobacter pylori infection were 31.4% and 29.9% in RE and NERD respectively (P>0.05).Conclusion: 24h pH Dynamic Monitoring is proved to be an objective and effective means of GERD diagnoses and treatment. And it's proved that between REand NERD patients, there are no discrepancies in esophageal acid exposure conditions and Helicobacter pylori infections. Acid regurgitation and Helicobacter pylori infection can not be taken as the determinator in NERD which has a different pathogenesis with RE.
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