| Nowadays, the incidence of cerebrovascular disease happened higher and higher. The clinical reports of CCS gradually increased. These that the pathogenesy, clinical manifestation and the changes of ECG in patients with CCS which caused by acute cerebrovascular disease and epileptic attack, had been demonstrated by a lot of materials.But the clinical studies of CCS's development, curative effect and prognosis were scarce. This experiment was about the changes of concentration of plasmic BNP and hs-CRP in patients with CCS.The clinical studies of CCS found that superior nerve center, which controlled heart actions, existed in hypothalamus, brain stem and limbic system. When acute stroke happened, brain tissues accepted more or less damages which can effect autonomic nerve center of hypothalamus, then produce various arrythmias and the pathological changes of cardiomyocytes. Simultaneously, the organisms lay in stress states and the levels of catecholamine and adrenaline were increased, which can result in the myocardial ischemia and damages and the increase of cardiomyocytes autorhythmicity and ectopic pacemaker. These can also result in arrythmias. When acute cerebullar diseases happened, some cell factors and phlogistic mediators released ,which can construct blood vessel, increase heart burden and inhibit energy metabolism of cardiomyocytes, then damage cardiomyocytes. Nowadays, many studies had found that the common causes of cerebrovascular disease were hypertension and angiosclerosis. Coronary arteriosclerosis and myocardial ischemia had existed in patiens with stroke. When stroke took place in these patients, the burdens of heart would increase and the original pathological changes would be provocated and aggravated. According to the pathogenesy, clinical manifestations of CCS and the clinical detectable significances, this experiment studied the changes and significances in patients respectively with CCS and simple arrhythmia through the two biochemical indicator of plasmic BNP and hs-CRP.BNP existed in central nurvous system(CNS) and acroteric tissues. In CNS, the concentration of BNP in medulla oblongata was the highest. In heart, the BNP mainly exsited in left and right cardiac atrium and the right one had the highest concentration. Nowadays, many researches found that plasmic BNP majorly came from cardiac ventricle. BNP was an effective index in detecting left ventricular function and a predictor of morbidity and mortality in heart disease. BNP was released from ventricular endothelium in response to ventricular stress, usually precipitated by either increased filling pressures or changes in ventricular compliance. Then the concentration of plasmic BNP would obviously increase. That the increase of the cardiac ventricular pressure,capacity load, ventricular dilatation and myocardial ischemia was the significant stimulus. BNP levels responsed to the range and serious grade of myocardial ischemic damages. These stimulant factors can also cause various abnomal electrophysiology. Some studies demonstrated that BNP had the roles of stimulating natriuresis and diuresis, dilating blood vessels, depressing pressure, inhibiting the activity of sympathetic nervous system and renin-angiotensin system. BNP stably exsited in blood plasm and its assay method was simple. Materials indicated that the relationship between the higher plasmic BNP concentration and arrhythmia was due to the myocardial ischemia, the dilatation of left ventricular volume and the increasing of left cardiac auricular and ventricular pressures. In CVD, whether cerebral hemorrhage or cerebral infarction, the contents of plasmic BNP in acute stage was higher than that in convalescence stage and control group. However, the more serious the patients'conditions, the more high the concentration of plasmic BNP.CRP was a non-specificity acute phase protein, which was related to many inflame diseases. When acute inflammatory reaction occured, the concentration of CRP obviously increased and the extent had a direct correlation with the level of tissue damages and infections. According to the cure of diseases, the content of CRP sharply dropped. The concentration of CRP stabilized in some scope and that the intermittent changes,such as time, seasons, et al, and the changes of food and drink had no effect on the level of CRP. So it can be detected at any time, and all results would have clinical reference values. Now more report had been existed, which was about the relation between atrial fibrillation and CRP. Through oxidative stress, inflammation effected the crucial pathophysiological course which concluded auricular structure and electrophysiology reconstitution, etc. Then that will effect the persistence and recurrence of atrial fibrillation. The materials about inflammation and stroke demonstrate that inflammatory reaction may damage the vessel wall and activate blood platelet, then caused aggregation and adhesion of blood platelet and formed unstable plaques. Infected factors ulteriorly promoted the focal inflammatory reactions in unstable plaques. Then that intensified vessel cell apoptosis, plaque ulcer and thrombus formation and evoked ischemia stroke. The plasmic CRP levels can predict the danger of myocardial infarction and stroke in future. When hemorrhagic cerebrovascular disease occurred, organism secreted plenty of cell factors stimulated by immunologic injury, then increased the concentration of CRP. Simultaneously, the compounds, that CRP resectively combined with C polycose, phosphatide and cation, can activate complements and produce a lot of C5a. These factors synergeticly facilitated the brain tissue'damages.BNP and hs-CRP was an original dangerous forecast index for cardiac cerebral vessels diseases. It's important for diagnosing cardiac cerebral vessels diseases, observing curative effect and judging the prognosis to observe the changes of plasmic BNP and hs-CRP concentrations. 34 patients in CCS and arrhythmia group and 22 health adults in control group had been selected in this experiment.BNP and hs-CRP were measured by immunity scatter turbidimetry and quantitative ELISA to detect the concerntration of hs-CRP and BNP. The results was that comparing with the control group, the concentration of plasmic BNP and hs-CRP both obviously increased in CCS and arrhythmia group(P<0.05). But the content of hs-CRP had no diffirence in arrhythmia group and control group (P>0.05), and the BNP had obvious diffirence in these two groups (P<0.05). Comparing CCS group and arrhythmia group, the concentrations of plasmic BNP and hs-CRP had obvious diffirence (P<0.05). Correlation analysis found that the concentration of plasmic BNP and hs-CRP had positive relation whether in arrhythmia group and CCS group. This experimental results can help to select rapid and precise biochemical indicator in clinic to effectively predict CCS, rationally select therapeutic regimens, observe curative effect and judge prognosis. Then these can developmently observe the changes of patients'condition, adjust therapeutic regimens in good time,release and remove the development of CCS. Through these measures, patients can acquire favourable turnovers and diminishi mortality.
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