Significance Of Mutant P53 Protein In Cervical Cancer Before And After Arterial Interventional Chemotherapy

Objective To detect the change of mutant P53 protein in cervical cancer before and after arterial interventional chemotherapy and to investigate the relationship between the protein and resistance to chemotherapeutics , therapeutic effect of arterial interventional chemotherapy. Methods Choose 27 cervical cancers during January 2003 to March 2004 from the first affiliated hospital of Nanchang University, 27-48 years old, average 34.22 ± 6.67 years, including Ⅱb 22 cases and Ⅲa 5 cases. None underwent radiotherapy, veno-chemotherapy and surgery before hospitalization. All cases were testified as squamous cell carcinoma by pathology. The examples from the cervix before and 3 - 4 weeks after arterial interventional chemotherapy were studied by means of immunohistochemistry. Results ①Expression of mutant P53 protein was seen in 33.33%(9/27) and 88.89%(24/27) of cervical cancer before and after arterial interventional chemotherapy, respectively. There was a significant difference between them(P<0.001). In addition, there were 2 cases positive before chemotherapy turned to negtive after arterial interventional chemotherapy, while others turned to positive from negtive. ②The total effective responsive rate was 62.96% (17/27) . There were 13 cases among negtive cases before arterial interventional chemotherapy and 4 cases from positive before, no difference between them. After 4 weeks of arterial interventional chemotherapy, the...