Expression Of Mutant P53 Protein And CyclinD1 Protein In Cervical Cancer

Objective : To investigate the expression of mutant P53 protein and Cyclin D1 protein in cervical cancer and the correlation between this two proteins.Methods:18 cases of normal tissues、10 cases of CINI、29 cases of CINII-III and 42 cases of cervical cancer tissues from 2012 to 2015 were selected.Immunohistochemical was performed to analysis the relationship between clinical and pathological features of cervical cancer.Results:(1)the positive expression rates of mutant P53 protein in normal cervical group, CINI group, CINII-III group and cervical cancer group were0%, 10%,44.82%, 66.71%, showed an increasing trend and the difference was statistically significant(x2=27.763,P < 0.05). The positive expression rates of Cyclin D1 protein in normal cervical group, CINI group, CINII-III group and cervical cancer group were 16.67%, 20.00%, 58.62%, 83.33%, the difference was statistically significant(x2=34.270,P<0.05).(2)The proteins were correlated with the degree of differentiation and lymph node metastasis(P< 0.05),but there were no significant correlation with pathological type and clinical stage(P > 0.05).(3)In cervical cancer, the expression of mutant P53 protein showed a positive correlation with Cyclin D1(R =0.305 P<0.05).Conclusion:the over expression of Cyclin D1 and mutant P53 may be related to the occurrence and development of cervical cancer, as well as the differentiation and malignant of cancer cells.The two proteins have a synergistic effect on the progress of cervical lesions.