| Objective: To study on the expression and clinical significance of estrogen receptor βERβ in breast cancer tissue. Methods:75 cases of primary breast cancer were collected and detected by S-P immunohistochemical for the express of estrogen receptor α ERα, ERβ and Progestin receptor PR with En Vision system. Those data were comparasively analysed for their, clinicopathological characters. Results: The ERP positive rate in 75 primary breast cancer tissues was 82.7%(62/75), and the ERβ was 46. 66% (35/75) in which ERα was positive, too. There was significant correlation between the expressions of ERP and ERα (P<0.05). The expression of ERβ was inversely correlated with histological degrees (P<0.05). The ERP positive rate showed 80%(28/35) in the axillary lymph node positive group, and while 47.5% (19/40) in the negative group, which had significant difference (p<0.05); The ERP positive expression in 45～50 year grade was obviously higher than that in the over year group, and interestingly the left breast was significantly higher than the right breast, p<0.05. Histology II was also showed significantly higher than that of I, p<0.05. The expression of ERβ had no correlation with tumor size, clinical stage and pathological type (P>0.05) Conclusion: (1)ERβ widely expresses in breast cancer tissues; ERP expresses much lower than ERα; Based on ERβ and ERα expresses together, there was no correlation between the...
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