The Study Of Serum Cytochrome C Level As A Prognostic Indicator In Critically Ill Patients

Objective:MODS have been one of the major complications and the reasones of death with the critically ill patients . Because there has no specific treatment measure, the death rate is quite high (40%~60%). With the steply development of understanding of organ disfunction and MODS, the clinic prevention and cure measure has been improved correspondingly, but the organ disfunction and MODS incidence rate and death rate has not been cut down. It has been thought that the key methods decreasing the mortality were to take earily pieriod forecasting the incidence of organ disfunction and MODS with critically ill patients for curing the syndrom.In recent years, there is increasing evidence that apoptosis may play an important role in the development of systemic inflammatory response syndrome (SIRS) and progression to multiple organ dysfunction syndrome (MODS) .In order to quantify the extent of apoptosis in critical ill patients ,we use a sandwich enzyme-linked immunosorbent assay kit(ELISA kit) system to measure serum cytochrome c levels and to study the level change of serum cytochrome c in critical ill patients ,and to determine its relationship to the tow representative organ dysfunction scores: APACHE II and SOFA score, and organ disfunction .From the research, we can take good preparation for the next step large scale clinical experiments to forecast the incidence of organ disfunction and MODS. Methods:The study was conducted in the medical intensive care unit of YanTaiShan...