Study Of Mifepristone In Small Dose On Recurrent Endometriosis Compared With Danazol

Objectives To investigate the clinic curative effects and side effects of mifepristone in small dose on endometriosis and serum estradiol (E2) level after conservative surgery.Approaches One hundred twenty-six patients with endometriosis after abdominoscope diagnosis were divided into M and D groups, with 72 and 54 people respectively. Group M were treated orally with mifepristone 10 mg/d and Group D danazol 200 mg on the basis of twice a day. Both courses of treatment lasted 3 months.Findings Remission rates by taking mifepristone in small dose on symptoms dysmenorrhea, hypogastralgia during non menstrual period, sexual intercourse pain, pelvic cavity tenderness, rear excavation tuberosity, womb movement restriction, aberrant ovary cyst size were 100% 71.43% 86.96% 83.33% 75.00% 77.78% 66.67% respectively. Whereas those by taking danazol 100% 83.33% 84.62% 83.33% 71.43% 72.73% 72.22% respectively. The differences in therapeutic effects between the two groups did not have any statistic significance (p>0.05). Before and after treatment, blood serum E2 levels of Group M were 97.08±19.69pmol/l 74.18±22.32 pmol/l, whereas those of Group D 100.77±16.62pmol/l 24.96±3.94pmol/l, which represented a significant difference after treatment(p<0.01). Serum estradiol (E2) levels in Group M remained in the range of follicular phase, but Group D declined to postmenopausal range. Endometrium thickness differences were not significant between the two groups. Besides, the thickness both remained in the normal sphere. After therapies were stopped, catamenia recurred in 27±8.9days and 40±12.4days for Group M and Group D separately. Catamenia recurred much faster for Group M than Group D. There was no big difference in blood total cholesterol, LDL, HDL before and after treatmen(tp>0.05). Incidence rates of tidal fever, irregular vagina bleeding, weight increase, abnormal ALT, gastrointestinaltract reaction and acne for Group M were 33.3% 19.44% 11.11% 2.78% 13.89% 0%, whereas for Group D 44.4% 22.22% 94.44% 5.56% 11.11% 33.33%. Incidence rates of weight increase and acne for Group M were much lower than those for Group D, with a significant statistical difference (p<0.01).Conclusions:I. Clinical symptoms of patients whose enjoyed remission in endometriosis in both groups.II. Therapy by 10mg/d mifepristone for 3 months can keep serum estradiol (E2) level within the range of follicular phase.III. Theray by mifepristone in small dose in treating recurrent endometriosis is safer and more effective. Besides, patients are to accept it more easily.IV. Theray by mifepristone in small dose in treating recurrent endometriosis will not result in lack of estrogen and ovulation recovers after therapy is suspended.V. Theray by mifepristone in small dose in treating recurrent endometriosis has not obvious impact on blood serum cortisol.VI. Theray by mifepristone in small dose in treating recurrent endometriosis has no impact on metabolism of blood fat.