A Primary Clinical Study Of ～1H MR Spectroscopy Imaging On Forepart Hepetocirrhosis After Chronic Type B Hepatitis

Objective: To investigate the feasibility of qualitative detecting forepart hepatocirrhosis after chronic type B hepatitis by ~1H Magnetic resonance spectroscopy (MRS) .Methods: 15 normal contrasts and 15 patients with forepart hepatocirrhosis after chronic type B hepatitis underwent ~1H MRS imaging. Compound peaks were acquired respectively and corrected by spectroscopy analysis GE (functool) software. The peak values were measured , the areas under the peaks were calculated and the features of normal contrasts and patients with forepart hepatocirrhosis after chronic type B hepatitis were analyzed by the software.Results: One protruded,high and peaky glumatic acid and glutamylamnnia complex (Glx) peak and the other plain and broad but low choline / phosphoric creatine acid( Cho / Pcr) peak appeared in the normal contrasts group, cases group acquired a Lactate (Lac) peak and Lipid (Lip) peak except above two peaks. Glx peak and Cho / Pcr peak have not obvious difference between these patients with forepart hepatocirrhosis after chronic type B hepatitis groups and normal contrasts groups(P > 0.05),but Lac peak and Lip peak have obvious difference(P < 0.05). Cases group can be separated to S2 stage , S3 stage and S4 stage according to results of liver biopsy , respective peak and the area under the peaks of GLX , Cho/pcr ,Lac and Lip have not significant difference ( P>0.05 ) .Conclusion: ~1H MRS imaging provides the possibility of qualitative detecting forepart hepetocirrhosis after chronic type B hepatitis. It is a non-invasive method of detecting forepart hepetocirrhosis after chronic type B hepatitis.