Clinical Research On QU-Bi-Tang

Ankylosing Spondylitis(AS) is a kind of chronic inflammatory and allergicdermatosis disease of the spine,axial skeleton and big jointofextremity,which is charactered by fibrosis,ossification,ankylosis inintervertebral disk annulus fibrosus and connective tissue nearly. Thetreatment of AS is very difficult.Up to the present,there is not a therapythat could cure AS totally.The AS patients need treatment or tracing in theirwhole life,which brings about serious pathological load or mental load topatient and enormous loss of social and economy. Lots of remedial westernmedicine now could improve the AS's symptoms, however,it would have nocommand over the AS progress. Moreover,with the extension of the medicinetime and the enlargement of dosage,it's effect would decline gradually andits poisonous side-effects would increase by degrees.Surgical operationonly apply to the afternoon patient whose spine hip and knee joint,are soabnormal,spastic seriously that effect on function.In the recent years,ithas been accepted by degrees to treat AS with TCM by more and more people. Peoplebelieve that TCM therapy could not only improve the AS' s symptom but alsocommand over the AS progress.Purpose:For young people, it is common that stagnation of damp-heat and deficiencyof blood and the Du meridian. It is effective clearing away heat evil, promotingdiuresis and promoting blood circulation,nourishing the Du meridian. Inthis study, we choose QU-Bi decoction,take a prospective random parallelismcomparison survey, by the observations of using QU-Bi decoction on stagnationof damp-heat and deficiency of blood and the Du meridian type AS,try to searchthe principle of TCM on the oncology and the treating methods of stagnation of damp-heat and deficiency of blood and the Du meridian syndrome AS,providebasic and clinical proves for the TCM syndrome differentiation.Although the course of AS is long and the treatment is difficult,itprovides a very long treatment time for us at the same time.Therefore,weshould make use of this good opportunity and develop the TCM treatment ofAS,which should make use of the direction that we work hard.This researchadopts the method of the clinical random parallelism comparison and observesthe AS NO. 3's clinical curative effect and security,trying to look for anew way to the AS.Method:This study elects the AS patient which syndrome is stagnation of damp-heatand deficiency of blood and the Du meridian as studied objects to take aprospective random parallelism comparison survey. We gained the random numbersfrom pens3.1 from windows which refer to EG:CG=1:1 amounting to 60. We dividedthe patients into 2 groups simply for the time that they came into ourhospital,and gave them QU-Bi decoction and Nimesulide(NIM) table or herbplacebo and Nimesulide(NIM) table referring to the randomization.The testran referring to the test requirement rigorously.At last,we collected 60cases.ALL cases of EG and CS has not been lost.Result:According to the comparison of age,family history,and the degree ofdysfunction of life before treatment is not significant,the basal line oftwo groups is coincident,and with comparability.The outcome shows: Contrast the integral of prior-treatment to which ofpost-treatment,the EG's integral of post-treatment of clinical symptom,the whole function,laboratory date and the obverse x-ray of the cacroiliacjoint has improved that of prior-treatment.The difference is significant(p＜0.05). The CG's integral of post-treatment of clinical symptom,thewhole function,laboratory date and the obverse x-ray of the cacroiliac jointhas improved than that of prior-treatment. The difference is significant (p＜0.05).However,the CG's integral of post-treatment of peripheral jointswell and the distance between head and wall is not improved significantly(p＞0.05).Contrast improvement rate of the integral two of post-treatment,interms of the improvement rate of the integral of clinical symptom, the whole function,laboratory date and the obverse x-ray of the cacroiliac joint, theEG is superior to the CG.The difference is significant (p＜0.05).But,interms of the distance between head and wall and expansion ratio on compagesof thorax, the difference of the two groups is not significant (p＞0.05).Conclusion:QU-Bi decoction is an effective decoction to cure AS which syndrome isstagnation of damp-heat and deficiency of blood and the Du meridian, it cansignificantly improve the patient' s clinical symptom, the whole function,laboratory date and the obverse x-ray of the cacroiliac joint. For the ASwhich oncology is stagnation of damp-heat and deficiency of blood and the Dumeridian,treating according to clearing away heat evil, promotingdiuresis and promoting blood circulation,nourishing the Du meridian canachieve clinical effectiveness. It is worth to be popularized and studiedfurther.