Expression Of C-fos And Integrin β₃ Subunit In Eutopic Endometrium During Implantation Window In Endometriosis

Objective: To investigate the mechanism of the effects of endome-triosis on humam endometrium receptivity and provide the knowledgefor treating endometriosis-induced infertility, C-fos protein and integrinβ₃ subunit were detected in eutopic endometrium during implantation win-dow.Methods: The endometrium was collected from 20 patients withendometriosis and 10 control patients during implantation window.Immunohistochemical method was used to investigate the expression ofc-fos protein and integrinβ₃ subunit in endometrium. The results wereanalysed by two-sample T test and linear Correlative Analyse.Results: The results of this study showed that endometrium frompatients with endometriosis expressed higher c-fos protein (P＜0.05).Themean gray scale of c-fos protein in eutopic endometrium during implan-tation window in endometriosis was 117.98±12.85and that in the con-trols was 136.04±17.86.Significantly fewer integrinβ₃ subunit wasexpressed compared with that in the controls (P＜0.05). The mean grayscale of integrinβ₃ subunit between the research subjects and controlswas141.63±13.27 and 110.78±12.88.No relationship between c-fos protein and integrinβ₃ subunit were found (r=-0.345,p＞0.05).Conclusion: First, it is found that c-los protein is increased inpatients with endometriosis,which may change the endometrial enviro-nment for embryo implantation. Second, integrinβ₃ subunit expressiondecreases significantly in patients with endometriosis as compared withthat in the controls, which may defect the human endometrium receptivityand interfer the implantation of blastocyst.