General Analysis Of 1809 Cases Drug Anaphylactic Shock Reports

The Adverse Drug Reaction (ADR) is the main question which in the medicationmeets, and the ADR monitoring is the most important responsibility for each country, it is also a method for them to ensure the drug security and safeguard health of thepublic. Some materials indicated causes the drug anaphylaxis as a result of theimmune system participation to respond probably occupies the ADR 1/6.The druganaphylaxis clinical manifestation was complex, involves the skin, the liver, thekidney, the heart and the hematopoietic system and so on many kinds of organizationsand the organ, the drug is connected gene in vivo distribution and metabolismcomplexity as well as the humanity gene polymorphism to decide its difficultpredictability. But the drug anaphylactic shock (DAS) is the clinical synthesis whichone kind acute, endangers life drafts, belongs to the systemic anaphylaxis that, occursis rapid, is fierce, forecast with difficulty, because the data quantity of this part ofinformation is big, lacks the systematic comprehensive gener.alized analysis.Therefore, compiles the analysis literature report drug anaphylactic shock case ofillness, summarizes characteristic, rule and influence factor which it occurs, to appliesdrugs care to propose own view, in order to help doctors to concretely understand thecharacteristic, the rule and the dangerous factor of this kind of ADR, the earlydiagnosis, the treatment, reduces its morbidity and the mortality, has the vitalsignificance regarding the instruction clinical reasonable medication.OBJECTIVE: To discuss the drug anaphylactic shock general rule, discover thedrug anaphylactic shock and the age, the sex, the medicine variety, the appear time, the administration route, the compatibility of medicines, the allergic history andformerly disease relations. Analyzes its characteristic and the influence factor, proposed significance and the method of the clinical drug care, provide the basis forthe reasonable medication METHODS: This research through the collection to the near five years medicalliterature report more than 2000 drug anaphylactic shock cases of reports, screens1809 cases, uses the review analysis method, using the computer auxiliary means, carries on reading to its content by, establishes the database, finally carries on thedatabase screening, compiles the analysis.RESULTS: In 1809 drug anaphylactic shock cases of reports, the male patientaccounts for 53.61ï¼…, the female patient accounts for 46.39ï¼…. The male and femaleproportion is 1: 1.16. Concern each age group. Involves the medicine 378 kinds, arranges in the first five distinctions is the anti-microorganism medicine, the Chinesenative medicine preparation, affects the blood and the hematopoietic system medicine, the biological preparations and the main function in the central nervous systemmedicine. In all medicines row of first three is the penicillin, the low moleculardextrose glycoside, the cordata houttuynia. The drug anaphylactic shock appears intime 30min accounts for 81.98ï¼…, involves many kinds of administration route, inwhich intravenous administration for 64.12ï¼…for the medicine, next (accounts for11.39ï¼…) for the intramuscular injection and the oral administration (accounts for9.45ï¼…) for the medicine. Some 25.87ï¼…patients have the allergic history or theallergy illness medical history, in the death case of reports this proportion is 33.33ï¼….CONCLUSIONS: The conclusion in summary, the drug anaphylactic shockinvolves the medicine to be widespread, the anti-infection medicine occupies the firstplace, next is the Chinese medicine preparation, the influence blood and thehematopoietic system medicine and makes the biological preparation; Each kindpossibly occurs for administration route, but the intravenous is higher than other forthe medicine to give the medicine way obviously; The shock appear time occurs mostin 30min, also has the minority case of illness or applies drugs continuously afterseveral hours occurs; In death case of illness has approximately 1/3 patients becausetransferred the courtyard treatment to delay the rescue time. Patient's age, the sex isnot the DAS influence factors, but patient formerly allergy history, allergy illness medical history and family allergy history, medicine itself structure, ingredient, quality as well as contact frequency as well as whether the reasonable medication isthe important influence factor. Drug anaphylactic shock organism aspect, medicineaspect and clinical reasonable medication influence, therefore, through inquiredearnestly with the recording drug allergy history, selects reasonably with the usemedicine enhances to the drug allergy understanding, specially enhances to the druganaphylactic shock understanding, the standard technical operation, consummatesmethods and so on rescue measure regarding to reduce DAS the occurrence, theprompt diagnosis and the treatment, reduces the mortality to play the positive role.