Studies On The Pharmacy Of Zhuyutongmai Drop Pills

Objective : To establish the optimum preparation process for Zhuyutongmai drop pills. Study its standard for quality control and test 3 batches of product according to ChP2005. To investigate the therapeutic effects of Zhuyutongmai drop pills on hyperviscosity and cardiovascular and cerebrovascular diseases (CVD) which laid a foundation for application in medical domain.Methods : To investigate the preparation technique and optimal formulation of Zhuyutongmai drop pills based on the studies of influential factors, optimal formulation was obtained by the orthogonal design. The pills was identified by TLC.The HPLC method was used to determine the content of chrysophanol . To determine the the weight deviation and disintegration time of the drop pills according to ChP2005. Studied the therapeutic effects of Zhuyutongmai drop pills on hyperviscosity and cardiovascular and cerebrovascular diseases (CVD) with the acute blood stasis model which was made by immersing the rats into ice-water bath and injecting adrenalin hydrochloride(i.p.). The thrombus formation in mice was induced by i.v injection of a mixture of collagen and epinephrine.Platelet aggregation was induced by ADP . The model of disturbance of cerebral circulation in mice was established by cutting mice's heads, and acute myocardium ischemia rat model was made by sublingual venous injection of Pit.Results :The main factors for drop pills′moulding technics were the choice of substrate,itsproportion of substrate to drug,the dropping and cooling agent temperature and dropping speed. The identified and determined of chrysophanol could be the standard for quality control. The results of experiment showed that Zhuyutongmai drop pills has the pharmacological action of promoting circulation to remove blood stasis.It could significantly inhibit the maximal aggregation rate of plateles, improve hemorheology and ischemic cardiac muscle, prolong the bleeding time and clotting time.Conclusion : Zhuyutongmai drop pills has significantly therapeutic effects on hyperviscosity and thrombus which is worthy of exploitation.