The Anti-cancer Effect Of Synthetic Serum Thymic Factor

Cancer impacts human health and induces death. In the few years,immunotherapy become a hot spot in the field of medicine and more andmore people pay close attention to it. It can not only inhibit the growth ofcancer cells but also adjust organism immunity.At present, the effect of thymosin praeparatum has been reported intumor and immunity. Serum thymic factor (FTS) is from thymus gland.It was consided that FTS can protect the mice from radiotherapy andchems. We have successfully synthesized FTS and proved it. Above thementioned, we explored the inhibition growth of different cancer cells byFTS. On the other hand, we inspected the immune function. The datafrom them can provid science evidence for the study ofpharmacodynamics and clinical application.In the initial stage, we constructed tumor model of KM mice. Theanimals were divided into five groups: high group, middle group, lowgroup, positive control and negative control. After given FTS, the trialgroups showed positive results. Then the results were confirmed again bytumor model of nude mice. It was showed that FTS inhibited cells growthof ascites tumor and solid tumor. In vitro, T cells were cultivated and MTT was tested the proliferationpotency. It was found that FTS had positive effect on T cells proliferationand OD value reaches peak at 0.016mg/ml. At the same time it is aturning point. The results after added Zn were better. Phagocytosis andthe degree of delayed hypersensitivity were detected, too. Compared withcontrol phagocytosis ability of the trial groups is stronger. The responseof delayed hypersensitivity in trial groups is more powerful than innegative control group. All of above, FTS may be modulate the immunityby nonspecific immunity and specific immunity cells.In conclusion, we reported for the first time FTS had inhibitory effecton cancer cells and modulated organism immunity condition. The studyresults could be powerful evidence for applying for new drug. In the sametime, it accumulated experimental basis for deeper study.