Exploration Of The Influence On Volume Of Bleeding In Functional Endoscopic Sinus Surgery By Prescribing Capsules Of Panax Notoginsena In Prophase Of Surgery For Curing Chronic Sinusitis

BackgroundEndoscopic Sinus Surgery (ESS) is a good way to treat Chronic Sinusitis (CS) and nasal polyps, but hemorrhage caused by the surgery is always a big problem puzzled surgeons. Bleeding made a negative influence on the vision of the surgery, enhanced the difficulty in dealing with the pathological changes due to hard to recognize the local anatomic structures, increased the risk of complications because of prolonged surgical time.ObjectiveThrough combining basic theory of Traditional Chinese Medicine in rules of "precaution for potential disease" and modern nasal endoscopic surgery, attend to explore the influence on volume of bleeding in Functional Endoscopic Sinus Surgery (FESS) and three indexes of cruor function, including prothrombin time (PT), activated partial thromboplastin time (APTT)and fibrinogen (FIB),by prescribing capsules of Panax notoginsena in prophase of surgery for curing chronic sinusitis.Methods80 patients diagnosed for chronic sinusitis of type 2, distributed randomly to therapy group and blank group in average. 40 cases in therapy group accepted regular treatment and dosage of capsules of Panax notoginsena, 40 cases in blank group were only given regular treatment but without capsules of Panax notoginsena. Comparing the difference of hemorrhage in surgery between these two groups and evaluating the changes in PT,APTT and FIB in each group, meanwhile, to compare the difference in results of volume of bleeding derived from two different calculating methods.ResultsThe average volume of bleeding in therapy group amounts to 132.8ml, the blank group is 167.8ml, there is no obvious difference in volume of bleeding between two groups (P＞0.05). Through treatment in prophase of surgery, PT,APTT and FIB in therapy group all dropped mildly, PT shortened 0.16s (P＜0.05), APTT dropped 1.85s (P＜0.01), FIB reduced 0.16g/L (P＜0.01); in blank group, PT prolonged 2.23s (P＞0.05), APTT dropped 0.79s (P＜0. 05), FIB reduced 0.01g/L (P＞0.05), and there are obvious difference, in PT, APTT nd FIB, between before and after accepting treatment above in prophase of surgery in therapy group (P＜0.05), but not in the blank group (P＞0.05). The average volume of bleeding in counting method A is 150. 3ml, and 149. 8ml in method B, no significance lies in difference between these two ways in calculating the volume of hemorrhage (P＞0.05). PT, APTT and FIB tested in entitled in hospital and in half an hour before surgery ali have no obvious significance between therapy and blank group (P＞0.05).ConclusionsOn the dosage of 3g per day taking Panax notoginsena capsules for two days, except for taking regular treatment, taking capsules of Panax notoginsena could reduce the average volume of bleeding adequately, but there is no obvious difference in volume of hemorrhage whether taking it or not. Taking capsules of Panax notoginsena could obviously reduce PT and APTT, and decrease FIB. There is no difference between A and B method in counting the volume of bleeding.