Expression And Clinical Significance Of CD44v6 And E-cadherin In Esophageal Squamous Cell Carcinoma

ObjectiveTo investigate the expression of CD44v6 and E-cadherin in esophageal squamous cell carcinoma and observe the correlation between CD44v6 and E-cadherin with biological behavior and invasion and metastasis.Material and MethodsImmunohistochemical staining was used to detect the expression of CD44v6 and E-cadherin in 91 cases of esophageal squamous cell carcinoma and 10 cases of normal esophageal tissues.ResultsIn 91 cases of esophageal squamous cell carcinoma, the expression of CD44v6 and E-cadherin were75.8 % and 47.3%. It was found that the positive expression rates of CD44v6 was positively related with invasion degree, clinical stages and lymph node metastasis. Meanwhile, abnormal expression rates of E-cadherin was negatively correlated with invasion degree, clinical stages and lymph node metastasis. The expression of CD44v6 was negative relatied to that of E-cadherin (r=-0.545, P＜0.01).ConclusionsThese data shows that the expression rate of CD44v6 and E-cadherin in esophageal squamous cell carcinoma was strongly related with invasion degree, clinical stages and metastasis. They might be the important biological marker in esophageal squamous cell carcinoma.