The Correlations Of Plasma Levels Of Leptin,Apolipoprotein A5 And Lipids In Male Patients With CHD

Objective: To explore the correlations of plasma levels of leptin, Apolipoprotein A5 and lipids in male patients with CHD.Methods: In this study, 80 male subjects were collected in the department of cardiology of 2^nd xiangya hospital from May and November 2006. They were divided into three groups, including 29 cases with acute coronary syndrome(ACS), 27 cases with stable angina(SA) and 24 controls, we measured the plasma levels of leptin, ApoA5 by enzyme linked immunosorbent assay and plasma levels of lipids by Hitachi 7660 analyzer. Then we compared the difference of leptin, ApoA5 between CHD subgroups and their correlations with lipids. All analysis was performed by SPSS13.0 software.Results: We found that①the plasma level of leptin was significantly higher in ACS group than in SA group and CG(P＜0.01), and in SA group it was higher than in controls(P＜0.05), plasma level of leptin was positively correlated with TG(r=0.68, P＜0.001), but there were no correlations were found between leptin and TC(r=-0.07, P=0.63), HDL-C (r=-0.02, P=0.89), LDL-C(r=-0.17, P=0.22);②)the plasma level of ApoA5 was lower in CHD group than in controls(P＜0.05), no difference in ACS group and SA group(P＞0.05). There were no correlations were found between ApoA5 and TG(r=-0.14, P=0.29), TC (r=0.21, P=0.13), HDL-C (r=0.19, P=0.18), LDL-C (r=0.22, P=0.11);③there were no correlation was found between leptin and ApoA5(r=-0.13, P=0.35).Conclusion:①Our study found that leptin may be a new plasma marker for CHD patients and take part in the process of lipids metabolism and CHD;②The plasma level of ApoA5 which is lower in CHD group is not correlated with lipids in male CHD patients;③The effects of leptin and ApoA5 on CHD and lipids metabolism are independent and irrelevant.