A Study Of Expression And Clinical Significance Of FHIT And Bax In Ovarian Carcinoma

Objective:Ovarian cancer is one of the leading mortality from gynecologicmalignancies. The cell apoptosis and the inactivation of a tumorsuppressor gene are closely related with tumorigenesis and progress.FHIT and Bax gene play an important role in enhancing a cell apoptosis.To investigation the expression of FHIT and Bax protein in ovariantumors, and to analyze the relation between FHIT,Bax andclinicpathological features(patient age,FIGO stage,tumor grade,histological subtype,residual tumor size and lymphnode metastasis) inorder to guide clinical diagnosis and evaluate prognosis.Methodes:20 samples of benign epithelial ovarian tumors, 15 samplesborderline epithelial ovarian tumors and 25 samples of epithelial ovariancarcinomas were examined for the expression of FHIT and Bax and theircorrelation by immunohistochemistry method.Results:1. Expression of FHIT in benign epithelial ovarian tumors,borderlineepithelial ovarian tumors and epithelial ovarian carcinomas was different (P＜0.05): None negative expression of the FHIT in benign andborderline epithelial ovarian tumors, but 7 of 25 cases(28%) of epithelialovarian carcinomas lost the expression of FHIT protein. The differencewas significant(P＜0.05);but the expression of FHIT from benignepithelia ovarian tumors to borderline epithelial ovarian tumors wasnot significant difference(P＞0.05).2. Among clinicopathological parameters of epithelial ovariancarcinomas (patient age,FIGO stage,tumor grade,histologicalsubtype,residual tumor size and lymphnode metastasis),FHIT expressionwas correlated with grade and lymphnode metastasis, FHIT expressionbecome decreased with advanced-grade and positive lymphnodemetastasis(P＜0.05).3. The expression of Bax in three groups was not statisticalsignificance(P＞0.05).4. Among clinicopathological parameters of epithelial ovariancarcinomas, Bax expression was significant in tumor grade(P＜0.05).5. Expression of FHIT had direct correlation with the expression ofBax(r_s=0.503, P＜0.05).Conclusions:1. Expression of FHIT in benign epithelial ovarian tumors andborderline epithelial ovarian tumors was not significant difference; expression of FHIT in epithelial ovarian carcinomas was remarkablydecreased. It was suggested that loss of FHIT expression could inducecarcinogenesis of epithelial ovarian tumors.2. In epithelial ovarian carcinomas, FHIT expression become decreasedwith advanced-grade and positive lymphnode metastasis. FHIT maycontribute the epithelial ovarian carcinomas to tumorigenesis andaggression. The abnormal FHIT expression was associated withprognosis.3. Expression of Bax in benign epithelial ovarian tumors, borderlineepithelial ovarian tumors and epithelial ovarian carcinomas was notsignificant different.4. Bax expression in epithelial ovarian carcinomas was correlated withtumor grade. This finding could indicate that Bax play a key role in cellapoptosis, as well as initiation and progression of epithelial ovariancarcinomas.5. Expression of FHIT had direct correlation with the expression of Bax.FHIT may be in coordination with Bax in carcinogenesis , progression ofepithelial ovarian tumors.