Study On The Chemical Constituents Of Craibiodendron Yunnanense

Craibiodendron yunnanense W. W. smith (family Ericaceae), a well known toxic plant, is an evergreen tree or shrub distributed mainly in hilly and valley regions of south, central, and northwest Yunnan Province of China. It has been reported that eating seven pieces of the plant leaves would put people in a coma state for more than one day. The dried plant leaves have been used as a Chinese folk medicine for relieving pain of arthritis, stomachalgia, paralysis, and as an insecticide in southwest region.The chemical constituents of Craibiodendron yunnanese which grow in Yunnan province of China have been investigated. From this plant, 10 compounds have been isolated, including one new secondary metabolites. Their structures were determined by spectral (1D- and 2D- NMR, MS, IR) methods to be (3β, 12β)-20(30)-taraxastene-3,12-diol ( 1 ), 3β-hydroxyurs-12-en-28-oic-acid ( 2 ),α-amyrin ( 3 ),β-amyrin ( 4 ),β-sitosterol ( 5 ), 2α, 3β, 23-trihydroxyurs-5, 12-dien-28-oic acid ( 6 ), 2α, 3β, 23-trihydroxyurs-12-en-28-oic acid ( 7 ), quercetin 3-O-β-D-glucopyranoside ( 8 ), 1-O-(β-D-glucopyranosyl)-(2S, 3S, 4R, 8Z)-2-[(2'R) -2'-hydroxydocosanoilamino]-8(Z)-octadecene-1, 3, 4-triol ( 9 ) and hexadecanamide (10). Compound 1 was a new natural product and compounds 2, 3, 4, 6, 8, 9, 10 were first found in this plant.