| Objective To describe distribution of plasma total homocysteine(tHcy) level and serum folic acid level in patients with mild-moderate hypertension from six cities of China, explore major effective factors of tHcy level, and analyze the relationship between serum folic acid level and tHcy level.Methods 456 patients with mild-moderate hypertension aged 18~75 years were randomly recruited from six cities in China. Plasma tHcy concentrations were measured using high-performance liquid chromatography (HPLC). Serum folic acid concentrations were measured using electrochemiluminescence.Results (1)Geometric mean of plasma tHcy was significantly higher in men than women(16.1μmol/L vs 11.3μmol/L, p < 0.01), moreover, prevalence rate of hyperhomocystinemia in male was also significantly higher than those in female (p< 0.05); (2) The significantly different mean of serum folic acid, 12.39 nmol/L in male and 14.61 nmol/L in female, was observed (p<0.01),moreover, the folic acid deficiency rate and lower folic acid rate in male was also significantly higher than those in female (p<0.05); (3) The plasma tHcy levels increasec with age in women, but not in men; (4) Folate and creatinine level effected plasma tHcy levels. Plasma tHcy levels negative correlate with folate level and positive correlate with creatinine level. Serum folic acid levels were lower, plasma tHcy levels were higher, and hyperhomocysteinemia prevalence rate were also higher.Conclusion Plasma tHcy and serum folic acid levels indicate gender differences in population with mild-moderate hypertension. Plasma tHcy levels is correlated with folate concentrations and renal functions. Plasma tHcy levels inversely correlates with folate level and positively correlates with creatinine level. It gives the clinical doctors useful information for better management of hyperhomocystinemia and helps to decrease potential risk of cardiovasvular event.
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