Expression And Significance Of PPARγ,COX-2 Bcl-2 In Cervical Intraepithelial Neoplasia And In Cervical Carcinoma

Objective: to study the expression of PPARγ, COX-2, bcl-2 in cervical intraepithelial neoplasia(CIN), cervical carcinoma and analyze the influence of cervical carcinoma. Methods :Envision immunohistological method were adopted to examine the expression of PPARγand compared between tumor specimens of cervical carcinoma(n=43) and CIN tissue (n=54)and normal cervix tissue (control n=20). SP were adopted to examine the expression of COX-2, bcl-2. Results: 1) The positive rates of PPARγwere0.00%(0/20), 55.36%(30/54), 76.74%(33/43) in normal cervical,CIN,cervical squamous cell carcinoma respectively. Compared with each group, expression of PPARγwas significantly enhanced (x~2 =38.942, P<0.01); The positive rates of PPARγwere 0.00%(0/20),70.83%(17/24), 82.61%(19/23), 55%(ll/20)and 0.00%(0/20), 54.16% (13/24),65.21%(15/23), 85%(17/20) in nucleus and matrix of normal cervical,CINIII,high differentiation and middle-low differentiation cervical carcinoma respectively. the positive freguency of PPARγin nucleus and matrix in each group was significant(x~2 =31.457, P＜0.01; x~2 =30.181, P＜0.01), but the positive frequency of PPARγin CINIIIand high differentiation carcinoma was not significant(Z=-1.752, P>0.05; Z=-0.568, P>0.05 and Z=-0.904, P>0.05; Z=-1.735, P>0.05). 2) The positive rates of COX-2 were 0.00%(0/20),51.85%(28/54), 83.72%(36/43)in normal cervical,CIN , cervical carcinoma respectively. Compared with each group, expression of COX-2 was significantly enhanced(x~2 =38.942, P＜0.01). 3) The positive rates of bcl-2 were10.00% (2/20), 53.70% (29/54), 76.74% (33/43)in normal cervical,CIN,cervical carcinoma respectively. Compared with each group, expression of COX-2 was significantly enhanced(x~2 =24.582, P＜0.01). 4) there was significant correlation between PPARγand COX-2, between PPARγand bcl-2 in cervical carcinoma(r=0.310, p=0. 043; r=0.342, P=0.025). Conclusion: Abnormal expression of PPARγ, COX-2, bcl-2 in CIN, cervical carcinoma indicate what were relation of occurring and development of cervical carcinoma. It was useful to forecast development of cervical carcinoma by combining to examine.