Changes Of Plasma Visfatin Levels And Relevant Factors In The Population With Different Glucose Tolerances

Objective: To investigate the changes of plasma visfatin levels and the relationship between plasma visfatin levels and body mass index (BMI), waist hip ratio (WHR), blood glucose, plasma insulin levels as well as other factors in the population with different glucose tolerances.Methods: Plasma visfatin levels in the fasting and glucose overload 2h were assayed by ELISA in the patients with type 2 diabetes (T2DM) and impaired glucose tolerance (IGT), and controls. The relationship between plasma visfatin levels and BMI, HOMA-IR, blood fat, plasma glucose, plasma insulin, free fatty acids(FFA)levels were also analyzed.Results: Fasting and 2h glucose overload plasma visfatin levels in T2DM were significantly reduced compared with controls(11.63±7.48 vs. 16.82±6.06, p < 0.01和12.02±6.86 vs. 16.26±7.78, p < 0.05),and the values of plasma visfatin in IGT were between T2DM and controls. The levels of visfatin in obese subjects were comparable with those in non-obese subjects. Plasma visfatin levels correlated positively with WHR(r= 0.42, p <0.01),and negatively with plasma glucose after glucose load (2hPG) and HbA1c(r=﹣0.33,p <0.01 and r=﹣0.25, p <0.05). Multiple regression analysis showed that WHR, high density lipoprotein-cholesterol (HDL-C) and HbA1c were independent related factors influencing plasma visfatin levels. Multiple logistic regression analysis revealed visfatin as an independent association factor for T2DM even after full adjustment of known biomarkers.Conclusion: The changes of visfatin levels are associated with glucose metabolism, and it may contribute, in part, to the pathogenesis of diabetes and obesity.