Relationship Between Genetic Polymorphism In Angiotensin-converting Enzyme, Angiotensin Ⅱ Type 1 Receptor And HBV-hepatic Cirrhosis

Objective: To investigate the relationship between genetic polymorphism in angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AT1R) and HBV-hepatic cirrhosis.Methods: Genetic polymorphisms in angiotensin-converting enzyme (NO. 16 intron I/D) and angiotensinâ…¡type 1 receptor (3'-UTR 1166A/C) were determined in 115 patients with HBV-hepatic cirrhosis and 136 healthy blood donors by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).Results: There was no significant difference in genotype distribution at NO. 16 intron I/D of ACE between the two groups. While among the patients with liver cirrhosis, the frequency of DD genotype in the patients with ascites was higher than those without ascites(27.78%VS 11.63%, P=0.042, P<0.05), and the frequency of the frequency of DD genotype in the Child C group was higher than the Child A and B groups. There were no significant differences at position 1166A/C of angiotensinâ…¡type 1 receptor between the liver cirrhosis group and the control group (P>0.05).Conclusion: The ACE gene polymorphism appears to be associated with HBV-hepatic cirrhosis: HBV-hepatic cirrhosis with DD genotype may be prone to develop ascites, and the DD genotype may play an essential role in the progression of hepatic fibrosis. These findings may have important therapeutic implications. But the mutation at position 1166A/C of angiotensinâ…¡type 1 receptor has no correlation with liver cirrhosis.