The Clinical Analysis Of 378 Cases With Non-Hodgkin's Lymphoma

The clinical analysis of 378 cases with non-Hodgkin's lymphoma1. Objective:To analyze the clinical characteristics of NHL.2. Methods:According to the World Health Organization classification of hematological and lymphoid tumors, 378 newly diagnosed patients with NHL from January 2002 to December 2005 were analysed retrospectively for the clinical states, involved sites, pathological classification, clinical stage and laboratory investigations.3. Results:1). The median age at onset was 51 years old. Male to female ratio was 1.4∶1. Out of 378 NHL cases, 87 cases (23.0%) were detected in nodal involvement, 62 cases (16.4%) were in extranodal sites, and 229 cases (60.6%) were in both sites. The most common sites of nodal involvement were in the cervical and supraclavicular parts, abdominal cavity and spleen. The most common sites of extranodal involvement were as follows: gastrointestinal tract, bone marrow, liver, skin, lung, bone and soft tissue, nasal cavity and paranasal sinuses, and central nervous system.2). The presents of different subtypes were as follows: 239 cases (65.5%) of B-cell and 126 cases (34.5%) of T/NK-cell, respectively. The subtypes of B-NHL were as follows: DLBCL, FL, MALT-MZL and CLL/SLL; The subtypes of T/NK-NHL were as follows: ALCL, MF, PTCL and NK/TCL.3). In NHL patients with leukopenia or anemia, there were significant differences between two groups who suffering from bone marrow involvement or not (P＜0.05). In NHL patients with leukocytosis or abnormal platelet count, there was no significant difference between two groups who suffering from bone marrow involvement or not (P＞0.05). 4). The elevated expression of ALT, AST and ALP in NHL cases between two groups who suffering from liver involvement or not were significant differences (P＜0.05). No significant difference was found in the elevated expression of GGT, TBIL and DBIL in NHL cases between two groups (P＞0.05).5). The positive rate of abnormal expression of serum LDH,β2-MG, ESR and CRP was 43.9%, 68.9%, 65.8% and 57.5%, respectively. The levels of LDH andβ2-MG in stagesⅢ/Ⅳwere higher than those in stagesⅠ/Ⅱ(P＜0.05). Otherwise the levels of ESR and CRP were no significant difference between stagesⅢ/Ⅳand stagesⅠ/Ⅱ(P＞0.05).4. Conclusion:1). The incidence of NHL in middle-aged patients is higher than others, the male patients is more than female patients, and the incidence of involvement in both nodal and extra- nodal sites is much more frequent.2). The incidence of B-cell NHL is higher than T/NK-cell NHL, different age groups have different pathological classification.3). We should pay attention to those with leukopenia or anemia to make sure if the patient suffering from bone marrow involvement.4). We should pay attention to those with abnormal elevated ALT, AST or ALP to make sure if the patient suffering from liver involvement.5). The serum levels of LDH andβ2-MG are associated with Ann Arbor staging classification.