The Clinical Value Of Hepatic Artery To Vein Transit Time For Diagnosis Liver Disease With Contrast Enhanced Ultrasound

Objective To compare the different methods measuring hepatic artery arriving time (HAAT) and hepatic vein arriving time (HVAT) by real time gray scale contrast ultrasonography,and explore the clinical value of the hepatic artery to hepatic vein transit time (HAVTT) for diagnosis liver disease with contrast enhanced ultrasound.Methods Seventy liver diseases patients(including 20 liver cirrhosis, 4 liver metastases,10 non-cirrhotic hepatic cell carcinoma,18 cirrhotic hepatic cell carcinoma,18 liver benign lesion)and 15 healthy volunteers in control group underwent real time gray scale contrast ultrasonography by vein rapid injection 0.6ml SonoVue,HAAT and HVAT were recorded,and HAVTT was calculated as the difference between HVAT and HAAT.HAAT and HVAT of 15 healthy volunteers were measured respectively by directly visualization of real time gray scale contrast ultrasonography and time-intensity cure analysis method,the results were compared to analyze the relativity.HAAT,HVAT and HAVTT of all case were analyzed after contrast enhanced ultrasound.Results The results of HAAT and HVAT measured by these two methods were no significant difference(P>0.05),and there was positive correlation between these two methods(r=0.926,P=0.000 and r=0.918,P=0.000).No significant difference was found in HAAT among each group(P>0.05).HVAT in liver cirrhosis group,liver metastases group,non-cirrhotic hepatic cell carcinoma group and cirrhotic hepatic cell carcinoma group were significantly earlier than those in liver benign lesion group and healthy group(P<0.01),and HAVTT in liver cirrhosis group,liver metastases group,non-cirrhotic hepatic cell carcinoma group and cirrhotic hepatic cell carcinoma group were significantly shorter than those in liver benign lesion group and healthy group(P<0.01).HVAT and HAVTT in liver cirrhosis group,liver metastases group,non-cirrhotic hepatic cell carcinoma group and cirrhotic hepatic cell carcinoma group were no significant difference(P>0.05),there were no significant difference in HVAT and HAVTT between liver benign lesion group and healthy group(P>0.05).Conclusions The results of HAAT and HVAT measured by directly visualization of real time gray scale contrast ultrasonography and time-intensity cure analysis method were no significant difference,there was positive correlation in results measured by these two methods.HAVTT can reflect hepatic homodynamic changes of liver diseases and have clinic value in diagnosis liver cirrhosis,benign liver tumor and malignant liver tumor by real time gray scale contrast ultrasonography.