The Relationship Between Plasma High-sensitivity C-reactive Protein,Interleukin-6 Levels On The Coronary Artery Disease

Objective: To discuss the relationship between plasma high- sensitivity C-reactive protein (hs-CRP),interleukin-6(IL-6)levels on the Coronary Artery Disease. Methods: 124 patients with coronary artery disease were included in the study. Among them, 71 male patients (57.3%), 53 female patients who were (42.7%),who were 28-79(58.62±10.55)years old. According to angiography there were single branch group, and multiple branches group(including double branches group,(angiography normal ) control group; The severity scale of coronary artery stenosis was quantatively assessed according to coronary angiography by Gensini score. So subdivided into control group (0 score, be angiography normal), <5 score group, 5-15 score group, >15 score group. The plasma hs-CRP and interleukin-6 levels were determined by Particle Enhanced Immune turbid metric Assay and using ELISA. Analyzed clinical datas of patients, for example age, BMI, smoking, blood pressure, lipid levels and blood glucose levels. After the influences from other risk factors of coronary artery disease were controlled by statistic method, the relationship between plasma hs-CRP,interleukin-6 levels and the Scope Severity of Coronary Artery Disease was analyzed. Results: Plasma hs-CRP,interleukin-6 levels of coronary artery disease groups were higher than control group obviously. Plasma hs-CRP,interleukin-6 levels in multiple branches group were higher than single branch group and control group; Plasma hs-CRP,interleukin-6 levels in higher score were higher than lower score group and control group; Conclusion: Plasma hs-CRP,interleukin-6 levels were correlated with of Coronary Artery Disease. Additional, Plasma hs-CRP,interleukin-6 levels may be able to be as new markers for surveillance on coronary artery disease stenonsis.